How are the Telomere test results?
The Patient Telomere Score is calculated based on the patient’s average telomere length in peripheral whole blood cells. This average is then compared to telomere lengths from a population sample in the same age range as the patient to determine the patient’s percentile score.
What do the results mean to the patient and the doctor?
Cellular attrition by analyzing the rate at which changes in average Telomere length occur over time. Cells are being lost and replaced. (Cellular attrition)
What are the nutritional implications on telomere length and repair?
An inflammatory diet, or one that increases oxidative stress, will shorten telomeres faster. This includes refined carbohydrates, fast foods, processed foods, sodas, artificial sweeteners, Tran’s fats and saturated fats. A diet with a large amount and variety of antioxidants that improves oxidative defense and reduces oxidative stress will slow telomere shortening. Consumption of 10 servings of fresh and relatively uncooked fruits and vegetables, mixed fiber, monounsaturated fats, omega-3 fatty acids, cold water fish, and high quality vegetable proteins will help preserve telomere length. In addition, it is advised to reduce total daily caloric intake and implement an exercise program. Fasting for 12 hours each night at least 4 days per week is recommended.
What lifestyle modifications are likely to be helpful?
One should achieve ideal body weight and body composition with low body fat (less than 22 % for women and less than 16 % for men). Decreasing visceral fat is very important. Regular aerobic and resistance exercise for at least one hour per day, sleeping for at least 8 hours per night, stress reduction, discontinuation of all tobacco products are strongly recommended.
When should retesting be considered?
Testing should be done once per year to evaluate the rate and direction of telomere changes and make adjustments in nutrition, nutritional supplements, weight management, exercise and other lifestyle modifications known to influence telomere length.
What role will nutritional supplements play in slowing telomere shortening?
Oxidative stress may shorten telomere length and cause aging in cellular tissue. Antioxidant supplements can potentially reduce oxidative stress very effectively, which will ultimately improve oxidative defenses, mitochondrial function, reduce inflammation and slow vascular aging. Targeted supplementation is key, as antioxidants work synergistically and must be balanced to work most effectively and avoid inducing a pro-oxidant effect
Specifically, studies have linked longer telomeres with levels of vitamin E, vitamin C, vitamin D, omega-3 fatty acids and the antioxidant resveratrol. In addition, homocysteine levels have been inversely associated with telomere length, suggesting that reducing homocysteine levels via folate and vitamin B supplementation may decrease the rate of telomere loss.
What pharmacologic treatments are known to slow telomere loss?
• Angiotensin converting enzyme inhibitors (ACEI)
• Angiotensin receptor blockers (ARB)
• Renin Inhibitors
• Statins
• Possibly Calcium channel blockers
• Possibly Serum aldosterone receptor antagonists
• Possibly metformin
• Aspirin
• Bio identical Hormone Replacement Therapy
Control all known coronary heart disease risk factors to optimal levels
• Reduce LDL cholesterol to about 70mg %, decrease
• LDL particle number and increase LDL particle size.
• Reduce oxidized LDL.
• Increase HDL to over 40mg % in men and over 50mg % in women and increase HDL 2 sub fraction. Reduce inflammatory HDL and increase protective HDL.
• Reduce fasting blood glucose to less than 90mg % and 2 hour post prandial or 2 hour GTT to less than 110mg %. Keep Hemoglobin A1C to about 5.0% and keep insulin levels low.
• Reduce blood pressure to about 120/80mm Hg
• Reduce homo cysteine to less than 8um/L
• Reduce HS-CRP to less than 1.0
• Maintain ideal body weight and composition.
• Stop smoking.
• Treat insulin resistance and metabolic syndrome.
Overall recommendations to maintain telomere length
Some clinicians have recommended reducing all known coronary risk factors, inflammation, oxidative stress, ADMA levels and angiotensin II levels or its action. At the same time, therapy should increase nitric oxide levels and nitric oxide bioavailability, increase arginine, increase endothelial progenitor cells, improve mitochondrial function and increase oxidative defenses. In addition, one should optimize hormone levels, exercise, sleep, nutrition and nutritional supplements. Fasting and caloric restriction should be part of the regimen as well.
Components
Telomeres are sections of genetic material at the end of each chromosome whose primary function is to prevent chromosomal “fraying” when a cell replicates. As a cell ages, its telomeres become shorter. Eventually, the telomeres become too short to allow cell replication, the cell stops dividing and will ultimately die—a normal biological process. Spectra Cell’s Telomere Test can determine the length of a patient’s telomeres in relation to the patient’s age.
Spectra Cell’s Telomere Test analyzes:
• Lysis of Cells
• DNA Extraction
• Amplification
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